Kathryn Grandfield » Faculty & Staff

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Kathryn Grandfield

Assistant Professor B.Eng., M.A.Sc. McMaster, Ph.D. Uppsala UniversityETB 403
Phone: (905) 525-9140, 23573 Website: Canadian Centre for Electron Microscopy Website: BIOMATCELL Centre of Biomaterials and Cell Therapy Website: Group Website
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Grandfield’s Research Group
Research Areas Include:
  • Biomaterials development for bone-interfacing applications
  • Osseointegration of titanium and ceramic implants
  • Electron tomography of biomaterials and biointerfaces
  • On-axis rotation electron tomography
  • Correlative microscopies of mineralized tissues
  • Biomineralization mechanisms
Current Openings
We regularly consider new additions to our lab group with experience or interest in biomaterials or electron microscopy. If you are interested in joining the group as a Master’s, PhD or summer undergraduate student, please email a current CV. Interested Post-Docs are also requested to send a short letter of research interests.
Biography
Prof. Grandfield earned a B.Eng. and Master’s of Applied Science in Materials Science and Engineering from McMaster University (2008, 2010), and a PhD from Uppsala University (2012). After spending several months as a visiting scientist at the University of Antwerp, she completed a post-doctoral position at the University of California, San Francisco. Prof. Grandfield is currently an Assistant Professor with the Department of Materials Science and Engineering and Associate Member of the McMaster School of Biomedical Engineering. Her research interests center on the improvement of electron microscopy techniques for biomaterials characterization and development, in particular on using focused ion beam microscopy and electron tomography to understand soft-hard tissue interfaces and mechanisms of biomineralization.

Selected Publications
  • Grandfield, K., Lev-Tov Chattah, N., Djomehri, S., Eidelmen, N., Eichmiller, F., Webb, S., Schuck, P.J., Nweeia, M., & Ho, S.P. (2014) The narwhal (Monodon monoceros) cementum-dentin junction (CDJ): A functionally graded biointerphase. Journal of Engineering in Medicine, accepted.
  • Grandfield, K. & Engqvist, H. (2014) Characterization of dental interfaces with electron tomography. Biointerphases, 9, 029001. http://doi.org/10.1116/1.4862096
  • Ho SP, Kurylo MP, Grandfield K, Hurng J, Herber R-P, Ryder MI, Altoe V, Aloni S, Feng J, & Webb S. (2013) The plastic nature of the human bone-periodontal ligament-tooth fibrous joint. Bone, 57(2):455-467.http://doi.org/10.1016/j.bone.2013.09.007
  • Forsgren, J., Frykstrand, S., Grandfield, K., Mihranyan, A., & Strømme, M. (2013). A Template-Free, Ultra-Adsorbing, High Surface Area Carbonate Nanostructure. PLoS ONE, 8(7), e68486.http://doi.org/10.1371/journal.pone.0068486
  • Grandfield, K., Gustafsson, S., & Palmquist, A. (2013). Where bone meets implant: the characterization of nano-osseointegration. Nanoscale, 5(10), 4302-4308. doi:10.1039/c3nr00826f
  • Grandfield, K., Pujari, S., Ott, M., Engqvist, H., & Xia, W. (2013). Effect of Calcium and Strontium on Mesoporous Titania Coatings for Implant Applications. Journal of Biomaterials and Nanobiotechnology, 04(02), 107–113. doi:10.4236/jbnb.2013.42014
  • Grandfield, K., Palmquist, A., & Engqvist, H. (2013). Three-dimensional structure of laser-modified Ti6Al4V and bone interface revealed with STEM tomography. Ultramicroscopy, 127, 48–52.doi:10.1016/j.ultramic.2012.07.007
  • Grandfield, K., Palmquist, A., & Engqvist, H. (2012). High-resolution three-dimensional probes of biomaterials and their interfaces. Philosophical Transactions of the Royal Society a-Mathematical Physical and Engineering Sciences, 370(1963), 1337–1351. doi:10.1098/rsta.2011.0253
  • Grandfield, K., Palmquist, A., Engqvist, H., Thomsen, P. Resolving the CaP-bone interface: A review of discoveries with light and electron microscopy. (2012) Biomatter, 2(1), 15-23. doi:10.4161/biom.20062
  • Grandfield, K., & Engqvist, H. (2012). Focused Ion Beam in the Study of Biomaterials and Biological Matter.Advances in Materials Science and Engineering, 2012, 1–6. doi:10.1155/2012/841961
  • Olofsson, J., Pettersson, M., Teuscher, N., Heilmann, A., Larsson, K., Grandfield, K., et al. (2012). Fabrication and evaluation of Si(x)N (y) coatings for total joint replacements. Journal of Materials Science: Materials in Medicine, 23(8), 1879–1889. doi:10.1007/s10856-012-4625-3
  • Palmquist, A., Grandfield, K., Norlindh, B., Mattsson, T., Brånemark, R., & Thomsen, P. (2012). Bone-titanium oxide interface in humans revealed by transmission electron microscopy and electron tomography. Journal of The Royal Society Interface, 9, 396–400. doi:10.1098/rsif.2011.0420
  • Xia, W., Grandfield, K., Hoess, A., Ballo, A., Cai, Y., & Engqvist, H. (2012). Mesoporous titanium dioxide coating for metallic implants. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 100(1), 82–93. doi:10.1002/jbm.b.31925
  • Grandfield, K., Ericson, F., & Sandén, B. (2012). Ultrastructural characterisation of the hydroxyapatite–coated pedicle screw and human bone interface. International Journal of Nano and Biomaterials, 4(1), 1–11.doi:10.1504/IJNBM.2012.048209
  • Grandfield, K., Palmquist, A., Ericson, F., Malmström, J., Emanuelsson, L., Slotte, C., et al. (2012). Bone Response to Free-Form Fabricated Hydroxyapatite and Zirconia Scaffolds: A Transmission Electron Microscopy Study in the Human Maxilla. Clinical Implant Dentistry and Related Research, 14(3), 461–469.doi:10.1111/j.1708-8208.2009.00270.x
  • Xia, W., Grandfield, K., Schwenke, A., & Engqvist, H. (2011). Synthesis and release of trace elements from hollow and porous hydroxyapatite spheres. Nanotechnology, 22(30), 305610. doi:10.1088/0957-4484/22/30/305610
  • Grandfield, K., Palmquist, A., Gonçalves, S., Taylor, A., Taylor, M., Emanuelsson, L., et al. (2011). Free form fabricated features on CoCr implants with and without hydroxyapatite coating in vivo: a comparative study of bone contact and bone growth induction. Journal of Materials Science: Materials in Medicine, 22(4), 899–906.doi:10.1007/s10856-011-4253-3
  • Grandfield, K., McNally, E. A., Palmquist, A., Botton, G. A., Thomsen, P., & Engqvist, H. (2010). Visualizing biointerfaces in three dimensions: electron tomography of the bone-hydroxyapatite interface. Journal of The Royal Society Interface, 7(51), 1497–1501. doi:10.1098/rsif.2010.0213
  • Grandfield, K., Sun, F., FitzPatrick, M., Cheong, M., & Zhitomirsky, I. (2009). Electrophoretic deposition of polymer-carbon nanotube–hydroxyapatite composites. Surface & Coatings Technology, 203(10-11), 1481–1487. doi:10.1016/j.surfcoat.2008.11.022

Co-Workers
Past Students
  • Carolyn Willems, (Materials Science and Engineering, 2013)
  • Samantha Ho (Materials Science and Engineering, NSERC USRA summer 2013)
  • Pauline Bialas (INP Phlema Grenoble, exchange summer 2013)
Categories: Faculty